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Hepatitis NewsJuly 2006Transition Therapeutics Inc. Announces 12-Week Data from HCV-I.E.T.
Phase I/II Clinical Trial Announces 12-week data from an open label, multi-centre
Phase I/II clinical trial evaluating the interferon enhancing product, HCV-I.E.T.,
in hepatitis C non-responders. Beliefs about Disease Severity and Lifestyle Changes among Patients
with Chronic Hepatitis C Major step in fight on hepatitis C VIHA targets $1.5 million to halve HIV/AIDS, Hep C High Body Mass Index and Hepatitis C Are Risk Factors for Posttransplant
Diabetes: Presented at WTC Ontario will still spend millions on Hep C victims McGuinty
Government Commends Federal Hepatitis C Funding Treatment for Hepatitis C Less Than Half as Likely if You Have No Insurance Hepatitis C virus enzyme sites revealed AVI BioPharma Announces Hepatitis C Virus Clinical Study Modification Low CD4 cell count and hepatitis C coinfection risk factors for acute
kidney failure in HIV-infected patients Hepatitis C ad blitz raises ethical qualms Hepatitis C testing urged Cholesterol drugs may treat hepatitis C - study Sexual dysfunction common for men with hepatitis C 85% of rural Chinese HIV-positives also have hepatitis C Jury indicts hepatitis C inmate for assault after spitting on guards Innogenetics reports preclinical data on prophylactic hepatitis C
vaccine and identification of neutralizing HCV antibodies with unique features Treating hepatitis C recurrence after liver transplantation“A new study on recurring hepatitis C in patients who underwent a liver transplant found that better results were achieved when using a combination of pegylated interferon (a longer-acting form of the drug) and the antiviral drug ribavirin than standard interferon and ribavirin. In addition, failure to respond to the therapy early on was useful in predicting whether it would ultimately succeed.”
Clinical Trials, Cohort Studies, and Pilot StudiesTreatment
effects and predictors of a 24-week course of interferon alpha-2b plus
ribavirin combination therapy for patients with chronic hepatitis C.
Tomimatsu
M, et al. J
Gastroenterol Hepatol. 2006 Jul;21(7):1177-1183. Immunogenicity of recombinant hepatitis B vaccine in treatment-naive and treatment-experienced chronic hepatitis C patients: The effect of pegylated interferon plus ribavirin treatment. Elefsiniotis IS, et al. World J Gastroenterol. 2006 Jul 21;12(27):4420-4. Sustained virological response to peginterferon plus ribavirin in chronic hepatitis C genotype 1 patients is associated with a persistent Th1 immune response. Trapero-Marugan M, et al. Aliment Pharmacol Ther. 2006 Jul 1;24(1):117-28. Re-treatment
of chronic hepatitis C patients after relapse: efficacy of peginterferon-alpha-2a
(40 kDa) and ribavirin. Baseline
immune activation as a risk factor for the onset of depression during interferon-alpha
treatment.
Pegylated-interferon
alpha 2a treatment for chronic hepatitis C in patients on chronic
haemodialysis. Anonymous
pilot study of hepatitis C virus prevalence in liver transplant surgeons. Health
benefits of antiviral therapy for mild chronic hepatitis C: randomised controlled
trial and economic evaluation.
Basic and Applied Science, Pre-Clinical StudiesHCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells. Ghaziani T, et al. J Hepatol. 2006 Jul;45(1):5-12. Epub 2006 Feb 3 Early impairment of hepatitis C virus specific T cell proliferation during acute infection leads to failure of viral clearance. Folgori A, et al. Gut. 2006 Jul;55(7):1012-9. Epub 2006 Feb 16. Induction of antigen-specific immune responses in vivo after vaccination with dendritic cells transduced with adenoviral vectors encoding hepatitis C virus NS3. Xiang M, et al. Viral Immunol. 2006 Summer;19(2):210-9. Clinical
and therapeutic implications of hepatitis C virus compartmentalization. Human
liver sinusoidal endothelial cells induce apoptosis in activated T cells: a
role in tolerance induction. Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse
model. Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine design. Smyk-Pearson S, et al. J Infect Dis. 2006 Aug 15;194(4):454-63. Epub 2006 Jul 12.
HIV/HCV CoinfectionChanges in hepatitis C virus (HCV) viral load and interferon-alpha levels in HIV/HCV-coinfected patients treated with highly active antiretroviral therapy. Bower WA, et al. J Acquir Immune Defic Syndr. 2006 Jul;42(3):293-7. Pegylated interferon alpha-2b plus ribavirin
for the treatment of chronic hepatitis C in HIV-coinfected patients. GB Virus C (GBV-C) Infection in Hepatitis C Virus (HCV)/HIV-Coinfected
Patients Receiving HCV Treatment: Importance of the GBV-C Genotype. Incidence
of and risk factors for severe hepatotoxicity of nelfinavir-containing
regimens among HIV-infected patients with chronic hepatitis C. Viral kinetics and early prediction of nonresponse to peg-IFN-alpha-2b plus ribavirin in HCV genotypes 1/4 according to HIV serostatus*. Moreno A, et al. J Viral Hepat. 2006 Jul;13(7):466-73. Immunosuppression, hepatitis C infection, and acute renal failure in HIV-infected patients. Franceschini N, et al. J Acquir Immune Defic Syndr. 2006 Jul;42(3):368-72.
Complementary and Alternative TherapiesRandomized double blind placebo-controlled trial of a Chinese herbal therapy (CH100) in chronic hepatitis C. Mollison L, et al. J Gastroenterol Hepatol. 2006 Jul;21(7):1184-8.
MiscellaneousAssessment of liver fibrosis by a noninvasive method of transient elastography
and biochemical markers. The Case of Scott Ortiz: A clash between criminal justice and public health. Venters HD, et al. Harm Reduct J. 2006 Jul 24;3(1):21 [Epub ahead of print]. The Impact of Chronic Hepatitis C and Comorbid Psychiatric Illnesses on Health-related
Quality of Life. Patients' experiences related to anti-viral treatment for hepatitis C. Fraenkel L, et al. Patient Educ Couns. 2006 Jul;62(1):148-55. Epub 2005 Aug 10. Lifestyle changes and beliefs regarding disease severity in patients with chronic hepatitis C. Castera L, et al. J Viral Hepat. 2006 Jul;13(7):482-8.
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