1. Wiley TE, McCarthy M, Breidi L, McCarthy M, Layden TJ. Impact of alcohol on the histological and clinical progression of hepatitis C infection. Hepatology. 1998;28(3):805-809.

2. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet. 1997;349(9055):825-832.

3. Zeuzem S. Heterogeneous virologic response rates to interferon-based therapy in patients with chronic hepatitis C: who responds less well? Ann Intern Med. 2004;140(5):370-81.

4. Regev A, Jeffers LJ. Hepatitis C and alcohol. Alcohol Clin Exp Res. 1999;23(9):1543-1551.

5. Schiff ER. The alcoholic patient with hepatitis C virus infection. Am J Med. 1999;107(6B):95-99S.

6. Ohta S, Watanabe Y, Nakajima T. Consumption of alcohol in the presence of hepatitis C virus is an additive risk for liver damage. Prev Med. 1998;27(3):461-469.

7. Caldwell SH, Jeffers LJ, Ditomaso A, et al. Antibody to hepatitis C is common among patients with alcoholic liver disease with and without risk factors. Am J Gastroenterol. 1991;86(9):1219-1223.

8. Pares A, Barrera JM, Caballeria J, et al. Hepatitis C virus antibodies in chronic alcoholic patients: association with severity of liver injury. Hepatology. 1990;12(6):1295-1299.

9. Coelho-Little ME, Jeffers LJ, Bernstein DE, et al. Hepatitis C virus in alcoholic patients with and without clinically apparent liver disease. Alcohol Clin Exp Res. 1995;19(5):1173-1176.

10. Mendenhall CL, Seeff L, Diehl AM, et al. Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: their prevalence and clinical relevance. The VA Cooperative Study Group 119. Hepatology. 1991;14(4 Pt 1):581-589.

11. Mendenhall CL, Moritz T, Rouster S, et al. Epidemiology of hepatitis C among veterans with alcoholic liver disease. The VA Cooperative Study Group 275. Am J Gastroenterol. 1993;88(7):1022-1026.

12. Corrao G, Arico S. Independent and combined action of hepatitis C virus infection and alcohol consumption on the risk of symptomatic liver cirrhosis. Hepatology. 1998;27(4):914-919.

13. Pessione F, Degos F, Marcellin P, et al. Effect of alcohol consumption on serum hepatitis C virus RNA and histological lesions in chronic hepatitis C. Hepatology. 1998;27(6):1717-1722.

14. Ostapowicz G, Watson KJ, Locarnini SA, Desmond PV. Role of alcohol in the progression of liver disease caused by hepatitis C virus infection. Hepatology. 1998;27(6):1730-1735.

15. Khan MH, Thomas L, Byth K, et al. How much does alcohol contribute to the variability of hepatic fibrosis in chronic hepatitis C? J Gastroenterol Hepatol. 1998;13(4):419-426.

16. Kondili LA, Tosti ME, Szklo M, et al. The relationships of chronic hepatitis and cirrhosis to alcohol intake, hepatitis B and C, and delta virus infection: a case-control study in Albania. Epidemiol Infect. 1998;121(2):391-395.

17. Frieden TR, Ozick L, McCord C, et al. Chronic liver disease in central Harlem: the role of alcohol and viral hepatitis. Hepatology. 1999;29(3):883-888.

18. Nevins CL, Malaty H, Velez ME, Anand BS. Interaction of alcohol and hepatitis C virus infection on severity of liver disease. Dig Dis Sci. 1999;44(6):1236-1242.

19. Loguercio C, Di Pierro M, Di Marino MP, et al. Drinking habits of subjects with hepatitis C virus-related chronic liver disease: prevalence and effect on clinical, virological and pathological aspects. Alcohol Alcohol. 2000;35(3):296-301.

20. Monto A, Patel K, Bostrom A, et al. Risks of a range of alcohol intake on hepatitis C-related fibrosis. Hepatology. 2004;39(3):826-34.

21. Bellentani S, Saccoccio G, Costa G, et al. Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study Group. Gut. 1997;41(6):845-50.

22. Roudot-Thoraval F, Bastie A, Pawlotsky JM, Dhumeaux D. Epidemiological factors affecting the severity of hepatitis C virus- related liver disease: a French survey of 6,664 patients. The Study Group for the Prevalence and the Epidemiology of Hepatitis C Virus. Hepatology. 1997;26(2):485-490.

23. Bellentani S, Tiribelli C, Saccoccio G, et al. Prevalence of chronic liver disease in the general population of northern Italy: the Dionysos Study. Hepatology. 1994;20(6):1442-1449.

24. Takase S, Tsutsumi M, Kawahara H, et al. The alcohol-altered liver membrane antibody and hepatitis C virus infection in the progression of alcoholic liver disease. Hepatology. 1993;17(1):9-13.

25. Donato F, Tagger A, Chiesa R, et al. Hepatitis B and C virus infection, alcohol drinking, and hepatocellular carcinoma: a case-control study in Italy. Brescia HCC Study. Hepatology. 1997;26(3):579-584.

26. Mori M, Hara M, Wada I, et al. Prospective study of hepatitis B and C viral infections, cigarette smoking, alcohol consumption, and other factors associated with hepatocellular carcinoma risk in Japan. Am J Epidemiol. 2000;151(2):131-139.

27. Khan KN, Yatsuhashi H. Effect of alcohol consumption on the progression of hepatitis C virus infection and risk of hepatocellular carcinoma in Japanese patients. Alcohol Alcohol. 2000;35(3):286-295.

28. Noda K, Yoshihara H, Suzuki K, et al. Progression of type C chronic hepatitis to liver cirrhosis and hepatocellular carcinoma - its relationship to alcohol drinking and the age of transfusion. Alcohol Clin Exp Res. 1996;20(1 Suppl):95-100A.

29. Oshita M, Hayashi N, Kasahara A, et al. Increased serum hepatitis C virus RNA levels among alcoholic patients with chronic hepatitis C. Hepatology. 1994;20(5):1115-1120.

30. Cromie SL, Jenkins PJ, Bowden DS, Dudley FJ. Chronic hepatitis C: effect of alcohol on hepatitic activity and viral titre. J Hepatol. 1996;25(6):821-826.

31. Zhang T, Li Y, Lai JP, et al. Alcohol potentiates hepatitis C virus replicon expression. Hepatology. 2003;38(1):57-65.

32. Sherman KE, Rouster SD, Mendenhall C, Thee D. Hepatitis C RNA quasispecies complexity in patients with alcoholic liver disease. Hepatology. 1999;30(1):265-270.

33. Ohnishi K, Matsuo S, Matsutani K, et al. Interferon therapy for chronic hepatitis C in habitual drinkers: comparison with chronic hepatitis C in infrequent drinkers. Am J Gastroenterol. 1996;91(7):1374-1379.

34. Okazaki T, Yoshihara H, Suzuki K, et al. Efficacy of interferon therapy in patients with chronic hepatitis C. Comparison between non-drinkers and drinkers. Scand J Gastroenterol. 1994;29(11):1039-1043.

35. Tabone M, Sidoli L, Laudi C, et al. Alcohol abstinence does not offset the strong negative effect of lifetime alcohol consumption on the outcome of interferon therapy. J Viral Hepat. 2002;9(4):288-94.

36. Loguercio C, Di Pierro M, Di Marino MP, et al. Drinking habits of subjects with hepatitis C virus-related chronic liver disease: prevalence and effect on clinical, virological and pathological aspects. Alcohol Alcohol. 2000;35(3):296-301.

37. National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C 2002 (June 10-12, 2002). Gastroenterology. 2002;123(6):2082-99.

38. Hezode C, Lonjon I, Roudot-Thoraval F, Pawlotsky JM, Zafrani ES, Dhumeaux D. Impact of moderate alcohol consumption on histological activity and fibrosis in patients with chronic hepatitis C, and specific influence of steatosis: a prospective study. Aliment Pharmacol Ther. 2003;17(8):1031-7.

39. Westin J, Lagging LM, Spak F, et al. Moderate alcohol intake increases fibrosis progression in untreated patients with hepatitis C virus infection. J Viral Hepat. 2002;9(3):235-41.

40. Ma X, Svegliati-Baroni G, Poniachik J, et al. Collagen synthesis by liver stellate cells is released from its normal feedback regulation by acetaldehyde-induced modification of the carboxyl-terminal propeptide of procollagen. Alcohol Clin Exp Res. 1997;21(7):1204-1211.

41. McClain C, Shedlofsky S, Barve S, Hill D. Cytokines and alcoholic liver disease. Alcohol Health Res World. 1997;21(4):317-320.

42. Lands WE. Cellular signals in alcohol-induced liver injury: a review. Alcohol Clin Exp Res. 1995;19(4):928-938.

43. Maher J, Friedman S. Pathogenesis of hepatic fibrosis. In: Hall P (Ed.). Alcoholic Liver Disease: Pathology and Pathogenesis. Oxford University Press. London, England. 1995.

44. Lieber CS. Hepatic and other medical disorders of alcoholism: from pathogenesis to treatment. J Stud Alcohol. 1998;59(1):9-25.

45. Lieber CS. Alcoholic liver disease: new insights in pathogenesis lead to new treatments. J Hepatol. 2000;32(1 Suppl):113-128.

46. Kurose I, Higuchi H, Kato S, Miura S, Ishii H. Ethanol-induced oxidative stress in the liver. Alcohol Clin Exp Res. 1996;20(1 Suppl):77-85A.

47. Gavaler J, Arria A. Increases susceptibility of women to alcoholic liver disease: Artifactual or real? In: Hall P (Ed.). Alcoholic Liver Disease: Pathology and Pathogenesis. Oxford University Press. London, England. 1995.

48.Tuyns AJ, Pequignot G. Greater risk of ascitic cirrhosis in females in relation to alcohol consumption. Int J Epidemiol. 1984;13(1):53-57.

49. Nicholls P, Edwards G, Kyle E. Alcoholics admitted to four hospitals in England. II. General and cause-specific mortality. Q J Stud Alcohol. 1974;35(3):841-855.

50. Patwardhan RV, Desmond PV, Johnson RF, Schenker S. Impaired elimination of caffeine by oral contraceptive steroids. J Lab Clin Med. 1980;95(4):603-608.

51. Johnson RD, Williams R. Genetic and environmental factors in the individual susceptibility to the development of alcoholic liver disease. Alcohol Alcohol. 1985;20(2):137-160.

52. Frezza M, di Padova C, Pozzato G, et al. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N Engl J Med. 1990;322(2):95-99.

53. Taylor JL, Dolhert N, Friedman L, et al. Alcohol elimination and simulator performance of male and female aviators: a preliminary report. Aviat Space Environ Med. 1996;67(5):407-413.

54. Kwo PY, Ramchandani VA, O'Connor S, et al. Gender differences in alcohol metabolism: relationship to liver volume and effect of adjusting for body mass. Gastroenterology. 1998;115(6):1552-1557.

55. Li T, Beard J, Orr W, et al. Gender and ethnic differences in alcohol metabolism. Alcohol Clin Exp Res. 1998;22(3):771-772.

56. Mochida S, Ohnishi K, et al. Effect of alcohol intake on the efficacy of interferon therapy in patients with chronic hepatitis C as evaluated by multivariate logistic regression analysis. Alcohol Clin Exp Res. 1996;20(95):371-377A.

57. Anon. Matching Alcoholism Treatments to Client Heterogeneity: Project MATCH posttreatment drinking outcomes. J Stud Alcohol. 1997;58(1):7-29.

58. Fleming M, Manwell LB. Brief intervention in primary care settings. A primary treatment method for at-risk, problem, and dependent drinkers. Alcohol Res Health. 1999;23(2):128-137.

59. Alcohol Alert No. 43. Brief intervention for alcohol problems. National Institute on Alcohol Abuse and Alcoholism. Bethesda, Maryland. 1999.

60. DiClemente CC, Bellino LE, Neavins TM. Motivation for change and alcoholism treatment. Alcohol Res Health. 1999;23(2):86-92.

61. Steinglass P. Family Therapy: Alcohol. In: Galanter M, Kleber H, (Eds.). The American Psychiatric Press Textbook of Substance Abuse Treatment. American Psychiatric Press. Washington, DC. 1999.

62. O'Farrell TJ. Marital and family therapy in alcoholism treatment. J Subst Abuse Treat. 1989;6(1):23-29.

63. Matching Alcoholism Treatments to Client Heterogeneity: Project MATCH posttreatment drinking outcomes. J Stud Alcohol. 1997;58(1):7-29.

64. Miller WR, Zweben A, DiClemente CC, Rychatrik R. Motivational Enhancement Therapy Manual. NIH Pub. No. 94-3723. National Institutes of Health. Rockville, Maryland. 1995.

65. Humphreys K, Mankowski ES, Moos RH, Finney JW. Do enhanced friendship networks and active coping mediate the effect of self-help groups on substance abuse? Ann Behav Med. 1999;21(1):54-60.

66. Tonigan JS, Toscova R, Miller WR. Meta-analysis of the literature on Alcoholics Anonymous: sample and study characteristics moderate findings. J Stud Alcohol. 1996;57(1):65-72.

67. Longabaugh R, Wirtz PW, Zweben A, Stout RL. Network support for drinking, Alcoholics Anonymous and long-term matching effects. Addiction. 1998;93(9):1313-1333.

68. Morgenstern J, Labouvie E, McCrady BS, et al. Affiliation with Alcoholics Anonymous after treatment: a study of its therapeutic effects and mechanisms of action. J Consult Clin Psychol. 1997;65(5):768-777.