Hepatitis C Caring Ambassadors Monthly Newsletter

March  2005

IN THE NEWS

 

Acetaminophen, When Taken as Directed, Appears Safe for Patients with Liver Disease

http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-93.html#1

 

Campaign Launched to Identify and Treat Hepatitis C Carriers http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-92.html

 

County Approves Syringe Program

http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-94.html

 

Diabetes Increases the Risk of Hepatocellular Carcinoma http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-92.html

 

Hepatitis C and Health-Related Quality of Life  http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-93.html#1

 

Hepatitis C Antibodies May Be Slow to Appear

http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-94.html

 

Hepatitis C Caring Ambassadors Program Launches Online Activist Resource Center

http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-93.html#1

 

Maxygen Announces Achievement of Milestone in Alliance with Roche http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-94.html

 

National Hepatitis C Advocacy Council Celebrates Reintroduction of Federal Hepatitis C Legislation

http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-92.html

 

Schering-Plough Will Provide Hepatitis C Treatment to ADAP Enrollees

http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-92.html

 

Senator Kay Bailey Hutchison (R-TX) and Representative Heather A. Wilson (R-NM) sponsor the reintroduction of The Hepatitis C Epidemic Control and Prevention Act (S-521, HR-1290) into both Houses of the 109th Congress.

http://biz.yahoo.com/bw/050316/165139_1.html

 

Singer Trying to Raise Hepatitis C Awareness

http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-92.html

 

Willie Nelson in hepatitis C PSA

http://www.hcvadvocate.org/news/newsRev/2005/NewsRev-93.html#1

 

CLINICAL TRIALS,COHORT STUDIES

 

 

Addressing tri-morbidity (hepatitis C, psychiatric disorders, and substance use): the importance of routine mental health screening as a component of a comanagement model of care. Fireman M, et al.  Clin Infect Dis. 2005; 40 Suppl 5: S286-91.   http://highwire.stanford.edu/cgi/medline/pmid;15768336?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111434249499_24242&stored_search=&FIRSTINDEX=10&fdate=3/10/2005&usestrictdates=yes

 

Advising patients with hepatitis C in primary care.  Drug Ther Bull. 2005 43(3): p. 22.

http://highwire.stanford.edu/cgi/medline/pmid;15762385

 

Associations among clinical, immunological, and viral quasispecies measurements in advanced chronic hepatitis C. Rothman AL, et al.  Hepatology. 2005 Mar;41(3):617-25. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15726656&dopt=Abstract

 

Association of Helicobacter species with hepatitis C cirrhosis with or without hepatocellular carcinoma. Rocha M, et al.  Gut. 2005 54(3): p. 396. http://highwire.stanford.edu/cgi/medline/pmid;15710989

 

Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey. Shan Y, et al. Clin Infect Dis. 2005;40(6):834-41. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15736017&dopt=Abstract

 

Autoimmune manifestations during interferon therapy in patients with chronic hepatitis C: the hepatologistis view. R Pellicano, et al. Minerva Gastroenterol Dietol. 2005 51(1): p. 55. http://highwire.stanford.edu/cgi/medline/pmid;15756146

 

Barriers to interferon-alpha therapy are higher in intravenous drug users than in other patients with acute hepatitis C. B Broers, et al. J Hepatol. 2005 42(3): p. 323.

 http://highwire.stanford.edu/cgi/medline/pmid;15791696

 

Changes in hepatitis C virus (HCV) antibody status in patients with  chronic hepatitis C after eradication of HCV infection by interferon therapy. Toyoda H, et al. Clin Infect Dis. 2005 40(6): p. 49.

http://highwire.stanford.edu/cgi/medline/pmid;15736006

 

Chronic hepatitis C treatment patterns in African American patients: an update. Daniel S.  Am J Gastroenterol. 2005;100(3):716-22. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15743373&dopt=Abstract

Course and treatment of recurrent Hepatitis C after liver transplantation. Neumann UP, Neuhaus P. Minerva Gastroenterol Dietol. 2004 50(1): p. 61.

http://highwire.stanford.edu/cgi/medline/pmid;15719007

 

Crohn's disease associated with interferon and ribavirin treatment for chronic hepatitis C. Khalil A, et al. Gastroenterol Clin Biol. 2005 29(2): p. 193. http://highwire.stanford.edu/cgi/medline/pmid;15795671

 

Distribution and risk factors of hepatitis B, hepatitis C, and HIV infection in a female population with "illegal social behaviour" Jahani MR, et al.  STI Online. 2005;  81(2): p. 185 http://sti.bmjjournals.com/cgi/content/extract/81/2/185?ct

 

Efficacy of a 24-week course of PEG-interferon alpha-2b monotherapy in patients with acute hepatitis C after failure of spontaneous clearance. Santantonio T, et al. J Hepatol. 2005;42:329-333.   

http://clinicaloptions.com/hep/news/news_imed_355.asp

 

Epidemiology and natural history of hepatitis C virus infection in injection drug users: implications for treatment. Sulkowski MS, Thomas DL.  Clin Infect Dis. 2005; 40 Suppl 5: S263-S269.   http://highwire.stanford.edu/cgi/medline/pmid;15768333?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111434820462_24550&stored_search=&FIRSTINDEX=20&fdate=3/10/2005&usestrictdates=yes

 

Epidemiology of hepatitis c virus infection. Bellentani S, et al. Minerva Gastroenterol Dietol. 2005; 51(1): 15-29.  http://highwire.stanford.edu/cgi/medline/pmid;15756151?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111437432218_25575&stored_search=&FIRSTINDEX=60&fdate=3/10/2005&usestrictdates=yes  

 

Estimation of Utilities for Chronic Hepatitis C from SF-36 Scores.  Thein HH, et al. Am J Gastroenterol. 2005 100(3): p. 643.

http://highwire.stanford.edu/cgi/medline/pmid;15743364

    

Factors Associated with Interest in Initiating Treatment for Hepatitis C Virus (HCV) Infection among Young HCV-Infected Injection Drug Users. Strathdee SA, et al. Clin Infect Dis. 2005; 40 Suppl 5: S304-12. http://highwire.stanford.edu/cgi/medline/pmid;15768339?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111435320231_24783&stored_search=&FIRSTINDEX=30&fdate=3/10/2005&usestrictdates=yes

 

Follow-Up Studies of Treatment for Hepatitis C Virus Infection among Injection Drug Users. Dalgard O. Clin Infect Dis. 2005; 40 Suppl 5: S336-8.  http://highwire.stanford.edu/cgi/medline/pmid;15768344?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111435320231_24783&stored_search=&FIRSTINDEX=30&fdate=3/10/2005&usestrictdates=yes


Four-year follow up of hepatitis C patients vaccinated against hepatitis B virus. Chlabicz S, et al. World J Gastroenterol. 2005 11(12): p. 1798. http://highwire.stanford.edu/cgi/medline/pmid;15793867

 

Hepatitis C reactivation in patients with chronic infection with genotypes 1b and 2c: a retrospective cohort study of 206 untreated patients Rumi MG, et al. Gut. 2005; 54(3): p. 402-406 

http://www.gutjnl.com/cgi/content/abstract/54/3/402?ct

 

Hepatitis C virus and non-Hodgkin's lymphoma 10 years later. Mazzaro C, et al.  Dig Liver Dis. 2005 37(4): p. 219.

http://highwire.stanford.edu/cgi/medline/pmid;15788203

 

Hepatitis C virus infection and injection drug users: prevention, risk factors, and treatment.

Backmund M, et al. Clin Infect Dis. 2005; 40 Suppl 5: S330-5.   http://highwire.stanford.edu/cgi/medline/pmid;15768343?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111435320231_24783&stored_search=&FIRSTINDEX=30&fdate=3/10/2005&usestrictdates=yes

 

Hepatitis C virus infection-related Type 1 diabetes mellitus. Chen LK, et al. Diabet Med. 2005 22(3): p. 340. http://highwire.stanford.edu/cgi/medline/pmid;15717885

 

Hepatitis C virus-induced hepatocellular steatosis. Castera L, et al. Am J Gastroenterol. 2005 ;100(3):711-5. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15743372&dopt=Abstract

 

Heterologous T cell immunity in severe hepatitis C virus infection. Urbani S, et al. J Exp Med. 2005 201(5): p. 675.

http://highwire.stanford.edu/cgi/medline/pmid;15753202

 

Immunology of hepatitis B virus and hepatitis C virus infection. Rehermann B, Nascimbeni M. Nat Rev Immunol. 2005 5(3): p. 215.

http://highwire.stanford.edu/cgi/medline/pmid;15738952

 

Impact of steatosis on progression of fibrosis in patients with mild hepatitis C. Fartoux L, et al. Hepatology. 2005;41(1):82-7.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15690484&dopt=Abstract

 

Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Romero-Gomez M, et al. Gastroenterology. 2005 128(3): p. 636.

http://highwire.stanford.edu/cgi/medline/pmid;15765399

 

Integrating services for injection drug users infected with hepatitis C virus with methadone maintenance treatment: challenges and opportunities.  Litwin AH, et al.  Clin Infect Dis. 2005; 40 Suppl 5: S339-45.  http://highwire.stanford.edu/cgi/medline/pmid;15768345?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111434820462_24550&stored_search=&FIRSTINDEX=20&fdate=3/10/2005&usestrictdates=yes

 

Lack of Evidence of Sexual Transmission of Hepatitis C Virus in a Prospective Cohort Study of Men Who Have Sex With Men  Alary M, et al.  Am J Public Health.  2005; 95(3): p. 502-5  http://www.ajph.org/cgi/content/abstract/95/3/502?ct

 

Lambda Interferon Inhibits Hepatitis B and C Virus Replication Robek MD, et al. Journal of Virology. 2005;79(6):3851-4.

http://www.medicalnewstoday.com/medicalnews.php?newsid=21496

 

Medical examinations at entry to treatment for drug abuse as an opportunity to initiate care for hepatitis C virus infection. Hagan H, et al. Clin Infect Dis. 2005; 40 Suppl 5: S297-303.   http://highwire.stanford.edu/cgi/medline/pmid;15768338?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111435320231_24783&stored_search=&FIRSTINDEX=30&fdate=3/10/2005&usestrictdates=yes

 

Mitochondrial dysfunction in hepatitis C.  Korenaga M, et al. J Clin Gastroenterol. 2005 39(4): p. S162.

http://highwire.stanford.edu/cgi/medline/pmid;15758653

 

Non-Hodgkin's lymphoma and other nonhepatic malignancies in Swedish patients with hepatitis C virus infection. Duberg AS, et al. Hepatology. 2005;41:652-659. http://clinicaloptions.com/hep/news/news_imed_360.asp

 

Overcoming barriers to prevention, care, and treatment of hepatitis C in illicit drug users. Edlin BR, et al. Clin Infect Dis. 2005;40 Suppl 5: p. S276.  http://highwire.stanford.edu/cgi/medline/pmid;15768335

 

Patients with cirrhosis and bare-stent TIPS may have increased risk of hepatocellular carcinoma.  Banares R, et al. Hepatology. 2005;41:566-571.  http://clinicaloptions.com/hep/news/news_imed_362.asp

 

Peginterferon alfa-2a does not alter the pharmacokinetics of methadone in patients with chronic hepatitis C undergoing methadone maintenance therapy. Sulkowski M, et al. Clin Pharmacol Ther. 2005;77:214-224.

http://clinicaloptions.com/hep/news/news_imed_363.asp

 

Pegylated Interferon vs Standard Interferon for Chronic Hepatitis C  Menkes DL. JAMA. 2005;  293(11): p. 1323

http://jama.ama-assn.org/cgi/content/extract/293/11/1323?ct

 

Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States. Bini EJ, McGready J. Hepatology, March 15, 2005. http://highwire.stanford.edu/cgi/medline/pmid;15770666?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111437082250_25428&stored_search=&FIRSTINDEX=40&fdate=3/10/2005&usestrictdates=yes

 

Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection. Schiefke I, et al. World J Gastroenterol. 2005 11(12): p. 1843. http://highwire.stanford.edu/cgi/medline/pmid;15793878

 

Screening for chronic hepatitis C American College of Preventive Medicine practice policy statement.  Hill L, et al. Am J Prev Med. 2005; 28(3): 327-30.  http://highwire.stanford.edu/cgi/medline/pmid;15766625?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111437082250_25428&stored_search=&FIRSTINDEX=40&fdate=3/10/2005&usestrictdates=yes

 

Sexual Transmission of HCV between Spouses.Tahan V, et al. Am J Gastroenterol. 2005;100(4):821-4. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15784025&dopt=Abstract

 

Treating hepatitis C virus infection in active substance users. Sylvestre DL.  Clin Infect Dis. 2005; 40 Suppl 5: S321-4. http://highwire.stanford.edu/cgi/medline/pmid;15768341?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111434249499_24242&stored_search=&FIRSTINDEX=10&fdate=3/10/2005&usestrictdates=yes

 

Treatment of hepatitis C: critical appraisal of the evidence. Camma C, et al. Expert Opin Pharmacother. 2005 6(3): p. 399.

http://highwire.stanford.edu/cgi/medline/pmid;15794731

 

 

CO-INFECTION

 

Challenges in the Treatment of Patients Coinfected with HIV and Hepatitis C Virus: Need for Team Care.

Fleming CA, et al. Clin Infect Dis. 2005; 40 Suppl 5: S349-54.   http://highwire.stanford.edu/cgi/medline/pmid;15768347?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111434249499_24242&stored_search=&FIRSTINDEX=10&fdate=3/10/2005&usestrictdates=yes 

 

Delivering Care to Injection Drug Users Coinfected with HIV and Hepatitis C Virus. Taylor LE. Clin Infect Dis. 2005; 40 Suppl 5: S355-61.   http://highwire.stanford.edu/cgi/medline/pmid;15768348?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111435320231_24783&stored_search=&FIRSTINDEX=30&fdate=3/10/2005&usestrictdates=yes 

 

Hepatitis C coinfection increases the risk of fulminant hepatic failure in patients with HIV in the HAART era. Kramer JR, et al. Hepatol. 2005 42(3): p. 309. http://highwire.stanford.edu/cgi/medline/pmid;15710213

 

Hepatitis C infection is not associated with systemic HIV-associated non-hodgkin's lymphoma: A cohort study. Waters L, et al.  Int J Cancer. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15756687&dopt=Abstract

 

Hepatitis C virus coinfection and HIV load, CD4+ cell percentage, and clinical progression to AIDS or death among HIV-infected women: Women and Infants Transmission Study. Hershow RC, et al.  Clin Infect Dis. 200540(6):859-67.  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15736020&dopt=Abstract

 

Integrating Treatment for Hepatitis C Virus Infection into an HIV Clinic. Clanon KA, et al. Clin Infect Dis. 2005; 40 Suppl 5: S362-6.   http://highwire.stanford.edu/cgi/medline/pmid;15768349?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111435320231_24783&stored_search=&FIRSTINDEX=30&fdate=3/10/2005&usestrictdates=yes 

 

Neuropsychiatric impact of hepatitis C on advanced HIV  Asnis GM, et al. Neurology. 2005;64(4): p. 768  

http://www.neurology.org/cgi/content/full/64/4/768?ct

 

Role of Liver Biopsy in the Evaluation of Hepatitis C Virus Infection in HIV Coinfection. Sterling RK. Clin Infect Dis. 2005; 40 Suppl 5: S270-5.    http://highwire.stanford.edu/cgi/medline/pmid;15768334?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111435320231_24783&stored_search=&FIRSTINDEX=30&fdate=3/10/2005&usestrictdates=yes

 

Treatment of acute hepatitis C infection in HIV-infected patients: a retrospective analysis of eleven cases. Vogel M, et al. J Viral Hepat. 2005 12(2): p. 207.

 http://highwire.stanford.edu/cgi/medline/pmid;15720537

 

 

 

OTHER RESEARCH

 

Addressing tri-morbidity (hepatitis C, psychiatric disorders, and substance use): the importance of routine mental health screening as a component of a co management model of care. Fireman M, et al. Clin Infect Dis. 2005;40 Suppl 5:S286-91. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15768336&dopt=Abstract

 

Cost effectiveness of testing strategies for chronic hepatitis C. Chapko MK, et al. Am J Gastroenterol. 2005;100(3):607-15. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15743359&dopt=Abstract

 

Impact of hepatitis C on health related quality of life: A systematic review and quantitative assessment. Spiegel BM, et al.  Hepatology. 2005;41(4):790-800. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15791608&dopt=Abstract

 

Psychiatric Barriers to Readiness for Treatment for Hepatitis C Virus (HCV) Infection among Injection Drug Users: Clinical Experience of an Addiction Psychiatrist in the HIV-HCV Coinfection Clinic of a Public Health Hospital. Scheft H, Fontenette DC. Clin Infect Dis. 2005; 40 Suppl 5: S292-6.  http://highwire.stanford.edu/cgi/medline/pmid;15768337?maxtoshow=&HITS=&hits=&RESULTFORMAT=&title=Hepatitis+C&andorexacttitle=and&titleabstract=Hepatitis+C&andorexacttitleabs=and&fulltext=Hepatitis+C&andorexactfulltext=and&searchid=1111435320231_24783&stored_search=&FIRSTINDEX=30&fdate=3/10/2005&usestrictdates=yes  

 

What's in a virus? Folk understandings of hepatitis C infection and infectiousness among injecting drug users in Kings Cross, Sydney. Southgate E, et al. Int J Equity Health. 2005 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15788093