Hepatitis C Caring Ambassadors Program Newsletter

April 2004

 

In The News

 

Hepatitis C scare halts use of surgical adhesive

http://www.yomiuri.co.jp/newse/20050427wo71.htm

 

 

Wait twelve weeks before treating acute HCV in HIV-positive patients.  Gilleece YC et al. Is the treatment of acute hepatitis C in HIV-positive individuals effective?. Eleventh Annual Conference of the British HIV Association, Abstract O26, Dublin, April 20 – 23rd, 2005.

http://www.aidsmap.com/en/news/414EA10C-33FB-4689-B586-8DB5F4A2CEF6.asp

 

Hepatitis C Can Be Sexually Transmitted

http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=8287010

 

Aethlon Medical Sends HIV-AIDS & Hepatitis-C Treatment Technology to India

http://home.businesswire.com/portal/site/google/index.jsp?ndmViewId=news_view&newsId=20050421005534&newsLang=en

 

Grits agree to extend hepatitis C benefits

http://www.theglobeandmail.com/servlet/story/RTGAM.20050420.wxhepc0421/BNStory/National/

 

Patients alerted over Hepatitis C:  A group of women who were treated at three Scottish hospitals are being screened for Hepatitis C.

http://news.bbc.co.uk/2/hi/uk_news/scotland/4460381.stm

 

Human Genome Sciences Hepatitis C Drug Passes Test

http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=8185669

 

New Data on Most Prescribed Hepatitis C Therapy Pegasys(R) Presented at European Association for the Study of the Liver (EASL) Conference:  Roche continues pioneering research to enhance treatment for hepatitis C patients

http://biz.yahoo.com/prnews/050415/nyf011.html?.v=5

 

McGuinty government appoints members of Hepatitis C Task Force:  Chair, 16-Member Panel To Examine Hepatitis C Prevention And Treatment [Canada]

http://www.newswire.ca/en/releases/archive/April2005/04/c1850.html 
 
Hepatitis C action 'inadequate’:  The government is not doing enough to stem a "tidal wave" of hepatitis C in the UK, MPs have said.
http://news.bbc.co.uk/1/hi/health/4369199.stm 
 
Hepatitis C Antibodies May Be Slow to Appear
http://www.reuters.com/newsArticle.jhtml?type=healthNews&storyID=8027746 
 
Hepatitis C Treatment Makes Economic Sense [New Zealand]
http://www.scoop.co.nz/stories/GE0504/S00002.htm 
 
Valeant Pharmaceuticals Presents Final Analyses of Viramidine Phase 2 Clinical Trial at EASL; Viramidine Phase 2 SVR Data Presented in Detail; Four Valeant Abstracts Accepted for Presentation at EASL
http://www.valeant.com/mediaCenter/newsArticle/newsArticle.jspf?objectId=4096 
 
Clinical Trials, Cohort Studies, Pilot Studies
 
Etanercept as an adjuvant to interferon and ribavirin in treatment-naive patients with chronic hepatitis C virus infection: a phase 2 randomized, double-blind, placebo-controlled study.  Zein NN, et al. J Hepatol. 2005 Mar;42(3):315-22.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15791697
 
Is the management of hepatitis C patients appropriate? A population-based study.  Hatem C, et al.  Aliment Pharmacol Ther. 2005 Apr 15;21(8):1007-15.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15813837 
 
Seroprevalence of hepatitis C virus and associated risk behaviours: a population-based study in San Juan, Puerto Rico.  Perez CM, et al. Int J Epidemiol. 2005 Mar 31; [Epub ahead of print].
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15802378 
 
Usefulness of combined measurement of serum bile acids and ferritin as additional prognostic markers to predict failure to reach sustained response to antiviral treatment in chronic hepatitis C.  Jorquera F, et al. J Gastroenterol Hepatol. 2005 Apr;20(4):547-54.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15836702 
 
Pegylated versus standard interferon-alpha in antiviral regimens for post-transplant recurrent hepatitis C: Comparison of tolerability and efficacy. Toniutto P, et al. J Gastroenterol Hepatol. 2005 Apr;20(4):577-582.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15836706 
 
The accuracy of the report of hepatic steatosis on ultrasonography in patients infected with hepatitis C in a clinical setting: A retrospective observational study. Hepburn MJ, et al.  BMC Gastroenterol. 2005 Apr 13;5(1):14 [Epub ahead of print].
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15829009&dopt=Abstract 
 
Additional effect of low iron diet on iron reduction therapy by phlebotomy for chronic hepatitis C. Kimura F, et al. Hepatogastroenterology. 2005 Mar-Apr;52(62):563-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15816478&dopt=Abstract 
 
Treatment of chronic hepatitis C in patients unresponsive to interferon. Interest of re-treatment combining interferon induction therapy and ribavirin (a multicenter pilot study). Causse X, et al. Gastroenterol Clin Biol. 2005 Feb;29(2):117-21.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15795657&dopt=Abstract  
 
Prevalence and significance of neurocognitive dysfunction in hepatitis C in the absence of correlated risk factors. McAndrews MP, et al. Hepatology. 2005 Apr;41(4):801-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15793853 
 
Late liver-related mortality from complications of transfusion-acquired hepatitis C. Kamitsukasa H, et al. Hepatology. 2005 Apr;41(4):819-25.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15793849&dopt=Abstract 
 
Peginterferon alfa-2b plus ribavirin treatment in children and adolescents with chronic hepatitis C. Wirth S, et al. Hepatology. 2005 Mar 25;41(5):1013-1018.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15793840&dopt=Abstract 
 
Prospective evaluation of community-acquired acute-phase hepatitis C virus infection.  Cox AL, et al.  Clin Infect Dis. 2005 Apr 1;40(7):951-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15824985 
 
Basic and Applied Science, Pre-Clinical Studies
 
Evolution of the intrahepatic T cell repertoire during chronic hepatitis C virus infection. Giuggio VM, Bonkovsky HL, Rothman AL. Viral Immunol. 2005;18(1):179-89.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15802962 
 
Transforming growth factor-beta1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection. Wang H, et al. World J Gastroenterol. 2005;11(13):1929-36.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15800982 
 
Effect of heptitis C virus core protein on cellular gene expression: specific inhibition of cyclooxygenase 2.  Jhaveri R, Kundu P, Shapiro AM, Venkatesan A, Dasgupta A. J Infect Dis. 2005 May 1;191(9):1498-506.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15809909 
 
Changes of ECM and CAM gene expression profile in the cirrhotic liver after HCV infection: Analysis by cDNA expression array.  Xu X, et al. World J Gastroenterol. 2005 Apr 14;11(14):2184-7.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15810090 
 
Early dynamics of hepatitis C virus in the circulation of chimpanzees with experimental infection.  Tanaka J, et al. Intervirology. 2005 Mar-Jun;48(2-3):120-3.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15812184 
 
Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance.  Oleksyk TK, et al. Genes Immun. 2005 Apr 7; [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15815689 
 
Immunogenic Properties of a Chimeric Plant Virus Expressing a Hepatitis C Virus (HCV)-Derived Epitope: New Prospects for an HCV Vaccine. Piazzolla G, et al.  J Clin Immunol. 2005 Mar;25(2):142-52.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15821891 
 
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Adinolphi LE, et al. Hepatology. 2005 Apr 15;41(5):995-1003.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15834927 
 
Upregulation of transferrin receptor 2 and ferroportin 1 mRNA in the liver of patients with chronic hepatitis C. Takeo M, et al. J Gastroenterol Hepatol. 2005 Apr;20(4):562-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15836704 
 
Mizoribine inhibits hepatitis C virus RNA replication: Effect of combination with interferon-alpha. Naka K, et al. Biochem Biophys Res Commun. 2005 May 13;330(3):871-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15809077&dopt=Abstract 
 
Hepatitis C virus replicates in peripheral blood mononuclear cells of patients with occult hepatitis C virus infection. Castillo I, et al. Gut. 2005 May;54(5):682-5.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15831916&dopt=Abstract 
 
Diagnosis of hepatitis C virus related acute hepatitis by serial determination of IgM anti-HCV titres. Sagnelli E, et al. J Hepatol. 2005 May;42(5):646-51.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15826712&dopt=Abstract
 
Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Clouston AD, et al. Hepatology. 2005 Apr;41(4):809-18.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15793848&dopt=Abstract 
 
Escape mutations alter proteasome processing of major histocompatibility complex class I-restricted epitopes in persistent hepatitis C virus infection. Kimura Y, et al. J Virol. 2005 Apr;79(8):4870-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15795272&dopt=Abstract 
 
HIV/HCV Coinfection
 
Response to interferon-based therapies in HIV-infected patients with chronic hepatitis C due to genotype 4.  Soriano V, et al.  Antivir Ther. 2005;10(1):167-70.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15751774 
 
Changing mortality rates and causes of death for HIV-infected individuals living in Southern Alberta, Canada from 1984 to 2003.  Krentz HB, Kliewer G, Gill MJ.  HIV Med. 2005 Mar;6(2):99-106.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15807715
 
HIV coinfection shortens the survival of patients with hepatitis C virus-related decompensated cirrhosis. Pineda JA, et al. Hepatology. 2005 Apr;41(4):779-89.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15800956 
 
Mitochondrial DNA depletion in liver tissue of patients infected with hepatitis C virus: contributing effect of HIV infection? Bauerle J, et al. HIV Med. 2005 Mar;6(2):135-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15807720 
 
Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine.  Cherner M, et al.  Neurology. 2005 Apr 7; [Epub ahead of print].  
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15817932 
 
HIV coinfection shortens the survival of patients with hepatitis C virus-related decompensated cirrhosis. Pineda JA, et al. Hepatology. 2005 Apr;41(4):779-89.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15800956&dopt=Abstract 
 
Complementary and Alternative Therapies
 
Oral silymarin for chronic hepatitis C - a retrospective analysis comparing three dose regimens.  Huber R, Futter I, Ludtke R.  Eur J Med Res. 2005 Feb 28;10(2):68-70.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15817425 
 
Oxidative stress in chronic hepatitis C: a preliminary study on the protective effects of antioxidant flavonoids. Emerit I, et al. Hepatogastroenterology. 2005 Mar-Apr;52(62):530-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15816472&dopt=Abstract 
 
Miscellaneous Works
 
In situ identification of hepatitis C virus RNA in muscle. Ito H, et al. Neurology. 2005 Mar 22;64(6):1073-5.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15781833 
 
Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment. Speigel BM, et al. Hepatology. 2005 Apr;41(4):790-800.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15791608 
 
Estimating the impact of hepatitis C virus therapy on future liver-related morbidity, mortality and costs related to chronic hepatitis C. Buti M, et al. J Hepatol. 2005 May;42(5):639-45.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15826711&dopt=Abstract 
 
Analytical variability of the Fibrotest proteins. Rosenthal-Allieri MA, et al.  Clin Biochem. 2005 May;38(5):473-8.  
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15820779 
 
Usefulness of the hepatitis C virus core antigen assay for screening of a population undergoing routine medical checkup.  Gaudy C. et al. J Clin Microbiol. 2005 Apr;43(4):1722-6.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15814991 
 
Biopsychosocial predictors of fatigue in chronic hepatitis C.  Hilsabeck RC, Hassanein TI, Perry W.  J Psychosom Res. 2005 Feb;58(2):173-178.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15820845 
 
Sexual transmission of HCV between spouses. Tahan V, et al.  Am J Gastroenterol. 2005 Apr;100(4):821-4.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15784025 
 
The hepatitis C crisis.  St John TM, Sandt L. Ethn Dis. 2005 Spring;15(2 Suppl 2):S52-7.  
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15822840 
 

Abstracts of interest:  40th Annual Meeting EASL, Apr. 13-17, 2005.  Paris, Fr.

NOTE:  Abstracts of the meeting can be searched for and viewed at http://www.kenes.com/easl2005sci/program/search.asp 
 
Modeling the natural course of chronic hepatitis C:  validation and clinical implications. Veldt BJ, et al.  Abstract 615.  
 
Long-term progression of fibrosis in patients with chronic hepatitis C (CHC) non-responders to interferon therapy (IFN). A longitudinal study of repeat liver biopsies.  Cirera I, et al. Abstract 555.  
 
Virologic response and safety outcomes in therapy-naïve patients treated for chronic hepatitis C with viramidine in combination with pegylated interferon alfa-2a. Gish RG, et al.  Abstract 91.

 

Tolerability and immunogenicity of HCV E1 therapeutic vaccination in patients with chronic hepatitis C on interferon plus ribavirin.  Horsmans Y, et al. Abstract 568.

 
Association between liver histology, viral kinetics and outcome of therapy with peginterferon alfa-2a combination therapy with ribavirin in interferon naïve patients with chronic hepatitis C.  Lagging M, et al. Abstract 574. 
 
Are current fibrosis serum markers really an alternative to liver biopsy in chronic hepatitis C? Leroy V, et al. Abstract 577.  
 
Peginterferon alfa-2a versus peginterferon alfa 2b in the treatment of chronic hepatitis C.  Mauss S, et al. Abstract 585. 
 
Differential TH1/TH2 cytokine profile of chronic hepatitis C patients with sustained virological response compared to non-responders and the effect of IFN plus ribavirin treatment. Par1 G, et al.  Abstract 451. 
 
Clustering of poor prognostic factors in patients with chronic hepatitis C.  Swain M, et al.  Abstract 607. 
 
Induction of the TH1/TC1 type immunity in chronic hepatitis C non-responder patients with the therapeutic peptide vaccine IC41. Wedemeyer H, et al. Abstract 19.
 
Evidence that serum ribavirin steady-state concentrations do not correlate with early virological response during peginterferon alfa-2a + ribavirin combination therapy for chronic hepatitis C.  Souvignet C, et al.  Abstract 606. 
 
Peginterferon alfa 2-b therapy in acute hepatitis C: impact of onset and duration of therapy on sustained virologic response.  Kamal S, et al.  Abstract 15. 
 
Fibrosis assessment in hepatitis C by computer-performed optical analysis of CT of the liver: a novel non-invasive and useful method.  Romero-Gomez M, et al.  Abstract 599. 
 
Does the clinical outcome of hepatitis C infection vary with the infecting hepatitis C virus type? Harris HE, et al. Abstract 567. 
 
Characteristics associated with progression of fibrosis in women with hepatitis C: evidence for the role of estrogen.  Codes L, et al.  Abstract 556. 
 
Enhanced antiviral efficacy for valopicitabine (NM283) plus peginterferon in hepatitis C patients with HCV genotype-1 infection: results of a phase 2a multicenter trial. Afdhal N, et al.  Abstract 93. 
 
Accurate models predicting response to pegylated interferon with ribavirin in patients with chronic hepatitis C as early as week 4. Martinot-Peignoux M, et al.  Abstract 584. 
 

Prediction of sustained virological response at week 4 of peginterferon alfa-2a plus ribavirin treatment in chronic hepatitis C patients with persistently normla ALT levels. Tran A, et al.  Abstract 612.

 
Is delivery mode related to perinatal transmission of hepatitis C virus (HCV). Mariné- Barjoan E, et al. Abstract 582. 
 
Development and validation of a simple model to predict response to peginterferon plus ribavirin combination therapy in genotype 1 chronic hepatitis C. Martínez-Bauer EM, et al. Abstract 583. 
 
Effect of maintenance peg-intron therapy on portal hypertension and its complications: results from the COPILOT study.  Curry M, et al.  Abstract 95. 
 
Modulation of interferon specific gene expression by albuferon ™ in subjects with chronic hepatitis C and correlation with antiviral response.  Moore P, et al.  Abstract 447.