Hepatitis C Challenge: Caring Ambassadors Hep C Program
 HepC Choices

Hepatitis News:

June 2007

Bipartisan Hepatitis C Legislation Reintroduced in Both Houses of Congress
"The Hepatitis C Epidemic Control and Prevention Act [SB-1445, HR-2552] has been reintroduced into both Houses of the 110th Congress by Senator Edward Kennedy (D-MA) and Representative Edolphus Towns (D-NY). The Hepatitis C Epidemic Control and Prevention Act mandates a comprehensive federal hepatitis C program to include counseling and testing, early detection, surveillance, education, training, and research. Originally introduced but not voted upon in 2003, the reintroduction of The Hepatitis C Epidemic Control and Prevention Act has been a bipartisan effort. The original cosponsors of the legislation are Senator Kay Bailey Hutchison (R-TX) and Representative Heather Wilson (R-NM)."

Hepatitis C On The Rise In Washington
"YAKIMA, Wash -- Hepatitis C is becoming one of the states top health concerns - with more than 100,000 people infected. Health officials say there about two hundred known case of Hepatitis C in Yakima County. That number is a slightly misleading because many people don't even know they have it."

Cellular Protein Found That Interferes With Hepatitis C Virus Replication
"Biomedical researchers have identified a cellular protein that interferes with hepatitis C virus replication, a finding that ultimately may help scientists develop new drugs to fight the virus. The anti-hepatitis C activity of the protein, called ,p21-activated kinase 1, (PAK1), was discovered by scientists at the University of Texas Medical Branch at Galveston (UTMB), who describe their findings in an article in the current issue of the Journal of Biological Chemistry."

A Cure For Hepatitis C Using Existing Treatments
"Researchers in the United States say they have discovered that people infected with hepatitis C can be cured with existing treatments."

Horror of Hepatitis Time Bomb [UK]

"Health experts are warning of a "hidden health timebomb" that could explode in Calderdale. Nearly 1,000 people in the area are already infected by hepatitis C â€" and many more may be unaware they are carrying the disease. If untreated, its infection can lead to potentially fatal liver disease and liver cancer."

The Gay Hep C Subculture
"A study of gay men with HIV who catch hepatitis C revealed sky-high levels of party drug use, unprotected sex, fisting and group sex among the men who get the virus, considerably higher than among men who don't.

After eliminating other causes for hep C transmission, researchers in three clinics in the United Kingdom found that unprotected group (rather than one-to-one) sex, unprotected anal sex and fisting were overwhelmingly more common in the men who caught hep C than a matched group of HIV-positive men who didn't. It also found that the vast majority of hepatitis C infections studied were linked with one of seven "clusters" of closely related hepatitis C viruses, the largest comprising nearly half of all those infected."

When HIV and Liver Disease Co-Exist
"Since successful antiretroviral therapies have made HIV a treatable condition, more HIV patients who are also infected with hepatitis B or C are experiencing the progression of their liver disease. In the face of this novel challenge, experts in the field convened to share information and opinions on the management of such patients."

Hepatitis C and Its Long-Term Effects Are a Growing Problem
"In the next decade, several million baby boomers will face the serious, long-term effects of the liver disease hepatitis C. Three to four million people in the United States and an estimated 100,000 in Massachusetts have chronic hepatitis C, compared to 1 million who have HIV."

Surviving Hepatitis C — Do You Harbor this Silent Killer?

"Five years ago, a woman named Sally in Seattle called me in Ohio to talk about her Hepatitis C. She was, as I recall, nearing 70 and a retired teacher. Her niece, an adult lawyer, had taken me to lunch to talk to me about her. She said Sally was the dearest sweetest woman; one whose husband was gone, had not had children, and was now alone. I was a columnist for the local newspaper and had been writing about my own Hepatitis C. For a year, I endured a clinical trial that was very much like chemotherapy. The niece told me Sally was afraid to have a liver biopsy, and wondered if I’d mind if her aunt called me."

Hepatitis C Drug Combo Shows Promise
"Doctors and researchers almost never use the word "cure," but they came as close as they ever do Monday when describing a combination of two drugs used to treat the severe liver disease hepatitis C, which is prevalent in South Florida. Among some patients, the drug cocktail of pegylated interferon and ribavirin completely kills the virus that causes hepatitis C, and keeps it from coming back, doctors said in reporting their new study at a Digestive Disease Weekly conference in Washington, D.C."

European Union's CHMP Issues Positive Opinion on PEGINTRON(Tm) and REBETOL(R) Combination Therapy for Hepatitis C in Patients Coinfected with HIV
"Schering-Plough Corporation today reported that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMEA) has issued a positive opinion recommending approval of combination therapy with PEGINTRON(TM) (peginterferon alfa-2b, 1.5 mcg/kg once weekly) and REBETOL(R) (ribavirin, 800 - 1,200 mg daily) for the treatment of previously untreated adult patients with chronic hepatitis C who are coinfected with clinically stable HIV. Approximately 40 percent of the estimated 2.5 million people living with HIV in Europe are coinfected with the hepatitis C virus (HCV), according to the World Health Organization (WHO)."

New Test Helps Identify Hepatitis C Patients at High Risk of Developing Cirrhosis
"A researcher at the Stanford University School of Medicine has helped confirm the reliability of a new test for liver disease that is ushering in the long-promised era of personalized medicine based on each individual's genetic makeup. The Stanford group was one of the five sites that helped determine that the genetic test can identify patients who are at high risk of developing cirrhosis from chronic hepatitis C infection. That means high-risk patients could be directed toward a long course of expensive, debilitating drug therapy, while low-risk patients might be better off delaying treatment. "

Nurses Say Many May Have Hepatitis C And Not Know It
"In their years treating patients at MetroWest Medical Center, nurses Kelly Lindebald and Lynn Dempsey have learned there is no such thing as a typical hepatitis C patient. Drug users who have shared needles may have it. So might a suburban stay-at-home mom who had a blood transfusion before 1990."

Alcohol and Hepatitis C Negatively Impact HIV
"Researchers at Boston Medical Center (BMC) and Boston University School of Public Health (BUSPH) have found that persons infected with the human immunodeficiency virus (HIV), who also have alcohol problems, were negatively affected by co-infection with the hepatitis C virus (HCV). These findings appear in the June issue of Alcoholism: Clinical Experimental Research."

Nautilus OK'd to Test Hep C Drug
PARIS, May 14 – "Nautilus said Monday the U.S. Food and Drug Administration cleared its potential hepatitis C treatment, oral Belerofon, for a phase 1 trial. Belerofon is a formulation of interferon-alpha that is intended to last longer in serum and reach blood levels comparable to those obtained by injected products."

Hep C Infection May Increase Risk of Lymphoma: Virus can hike chances of immune-system cancer by 30 percent, experts say
WASHINGTON – "Infection with the hepatitis C virus, already linked to liver cancer and cirrhosis, also increases the risk of developing non-Hodgkin’s lymphoma, a cancer of the immune system, researchers said on Tuesday.

Researchers tracked 146,394 U.S. military veterans infected with the virus and 572,293 veterans who were not, and found that hepatitis C infection boosted the risk for non-Hodgkin’s lymphoma by 20 percent to 30 percent."

clinical trials, cohort studies, and pilot studies

Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Sarrazin C, et al. Gastroenterology. 2007 May;132(5):1767-77. Epub 2007 Feb 21.

A randomized trial of induction doses of interferon alone or in combination with ribavirin or ribavirin plus amantadine for treatment of nonresponder patients with chronic hepatitis C. Gramenzi A, et al. J Gastroenterol. 2007 May;42(5):362-7. Epub 2007 May 25.

Thyroid Cancer in HCV-Related Chronic Hepatitis Patients: A Case-Control Study. Antonelli A, et al. Thyroid. 2007 May;17(5):447-51.

Effects of dietary iron reduction versus phlebotomy in patients with chronic hepatitis C: results from a randomized, controlled trial on 40 Japanese patients. Sumida Y, et al. Intern Med. 2007;46(10):637-42. Epub 2007 May 24.

Paroxetine for prevention of depressive symptoms induced by interferon-alpha and ribavirin for hepatitis C. Raison CL, et. al. Aliment Pharmacol Ther. 2007 May 15;25(10):1163-74.

A randomized study on Peg-interferon alfa-2a with or without ribavirin in liver transplant recipients with recurrent hepatitis C. Angelico M, et. al. J Hepatol. 2007 Jun;46(6):1009-17. Epub 2007 Feb 5.

Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus. Giordano TP, et.al. JAMA. 2007 May 9;297(18):2010-7

Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis. Pekow JR, et. al. Cancer. 2007 May 8;109(12):2490-2496 [Epub ahead of print]

High incidence of hepatitis C virus reinfection within a cohort of injecting drug users. Micallef JM, et. al. J Viral Hepat. 2007 Jun;14(6):413-8

Hepatitis C Virus Infection and the Development of Type 2 Diabetes in a Community-based Longitudinal Study. Wang CS, et. al. Am J Epidemiol. 2007 May 11; [Epub ahead of print]

Survival outcomes in liver transplantation for hepatocellular carcinoma, comparing impact of hepatitis C versus other etiology of cirrhosis. Bozorgzadeh A, et. al. Liver Transpl. 2007 May 30;13(6):807-813 [Epub ahead of print]

Mutation Rate of the Hepatitis C Virus NS5B in Patients Undergoing Treatment With Ribavirin Monotherapy. Lutchman G, et. al. Gastroenterology. 2007 May;132(5):1757-66. Epub 2007 Mar 24

Cognitive function does not worsen during pegylated interferon and ribavirin retreatment of chronic hepatitis C. Fontana RJ, et. al. Hepatology. 2007 May;45(5):1154-63

Liver fibrosis is associated with decreased peripheral platelet count in patients with chronic hepatitis B and C. Karasu Z, et. al. Dig Dis Sci. 2007 Jun;52(6):1535-9. Epub 2007 Apr 27

Antiviral response of HCV genotype 1 to consensus interferon and ribavirin versus pegylated interferon and ribavirin. Sjogren MH, et. al. Dig Dis Sci. 2007 Jun;52(6):1540-7. Epub 2007 Apr 4

Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. Pockros PJ, et al. J Hepatol. 2007 May 4; [Epub ahead of print]

Baseline cholesterol is associated with the response to antiviral therapy in chronic hepatitis C. Economou M, et al. J Gastroenterol Hepatol. 2007 May 13; [Epub ahead of print]

Look-back study of Hepatitis C in teenagers after blood transfusions as neonates. Michal K, et al. Acta Paediatr. 2007 May 10; [Epub ahead of print]

Trends in post-liver transplant survival in patients with hepatitis C between 1991 and 2001 in the United States. Thuluvath PJ, et al. Liver Transpl. 2007 May;13(5):719-24.

The impact of insulin resistance, serum adipocytokines and visceral obesity on steatosis and fibrosis in patients with chronic hepatitis C. Lo Iacono O, et al. Aliment Pharmacol Ther. 2007 May 15;25(10):1181-91.

Diabetes mellitus reduces the therapeutic effectiveness of interferon-alpha2b plus ribavirin therapy in patients with chronic hepatitis C. Konishi I, et al. Hepatol Res. 2007 May;37(5):331-6.

A 5-year prospective study of the late resolution of chronic hepatitis C after antiviral therapy. Annicchiarico BE, et al. Aliment Pharmacol Ther. 2007 May 1;25(9):1039-46..

basic and applied science, pre-clinical studies

Factors Affecting Serum Concentrations of Hepatitis C Virus (HCV) RNA in HCV Genotype 1-Infected Patients with Chronic Hepatitis. Ticehurst JR, et al. J Clin Microbiol. 2007 May 30; [Epub ahead of print]

Cell surface expression of LDL-Receptor in chronic hepatitis C: correlation with viral load. Petit JM, et al. Am J Physiol Endocrinol Metab. 2007 May 1; [Epub ahead of print]

Monitoring the anti-viral effect of interferon-alpha on individual cells. Kim CS, et al. J Virol. 2007 May 30; [Epub ahead of print]

An infectious hepatitis C virus (HCV) cDNA clone (JFH1) was generated recently. However, quantitative analysis

Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus. Lavillette D, et al. J Virol. 2007 May 30; [Epub ahead of print]

Hepatitis C virus p7 and NS2 proteins are essential for infectious virus production. Jones CT, et al. J Virol. 2007 May 30; [Epub ahead of print]

Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02. Smyth CM, et.al. Eur J Gastroenterol Hepatol. 2007 Jun;19(6):493-498

An assessment of serum leptin levels in patients with chronic viral hepatitis: a prospective study. Manolakopoulos S, et. al. BMC Gastroenterol. 2007 May 31;7(1):17 [Epub ahead of print]

Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus. Yee LJ, et. al. Hepatology. 2007 May 24; [Epub ahead of print]

Monocyte-derived dendritic cell function in chronic hepatitis C is impaired at physiological numbers of dendritic cells. MacDonald AJ, et. al. Clin Exp Immunol. 2007 Jun;148(3):494-500. Epub 2007 Mar 15

Progression of Fibrosis during Chronic Hepatitis C Is Associated with Rapid Virus Evolution. Wang XH, et. al. J Virol. 2007 Jun;81(12):6513-22. Epub 2007 Feb 28

NS3 helicase and NS5B to 3' X regions are important for efficient JFH-1 replication in Huh7 cells. Murayama A, et. al. J Virol. 2007 May 23; [Epub ahead of print]

MRP2 haplotypes confer differential susceptibility to toxic liver injury. Choi JH, et. al. Pharmacogenet Genomics. 2007 Jun;17(6):403-415

Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells. Novo E, et. al Am J Pathol. 2007 Jun;170(6):1942-53

Pretreatment sequence diversity differences in the full-length Hepatitis C Virus open reading frame correlate with early response to therapy. Donlin MJ, et al. J Virol. 2007 May 23; [Epub ahead of print]

Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection. Andréo U, et al. Cell Microbiol. 2007 May 21; [Epub ahead of print]

Hepatitis C virus induces the proteolytic cleavage of sterol regulatory element binding proteins (SREBPs) and stimulates the phosphorylation of SREBPs via oxidative stress. Waris G, et al. J Virol. 2007 May 16; [Epub ahead of print]

Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs. Chevalier C, et al. Mol Ther. 2007 May 15; [Epub ahead of print]

Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol. Pécheur EI, et al. Biochemistry. 2007 May 22;46(20):6050-9. Epub 2007 Apr 25.

hiv/hcv co-infection

Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. Danta M, et al. AIDS. 2007 May 11;21(8):983-991.

Awareness of hepatitis C diagnosis is associated with less alcohol use among persons co-infected with HIV. Tsui JI, et. al. J Gen Intern Med. 2007 Jun;22(6):822-5. Epub 2007 Feb 23

Hematologic toxicity associated with interferon-based hepatitis C therapy in HIV type 1-coinfected subjects. Behler CM, et. al. Clin Infect Dis. 2007 May 15;44(10):1375-83. Epub 2007 Apr 12.

Critical role of ribavirin for the achievement of early virological response to HCV therapy in HCV/HIV-coinfected patients. Ramos B, et. al. J Viral Hepat. 2007 Jun;14(6):387-91

Impact of hepatitis C on HIV progression in adults with alcohol problems. Cheng DM, et. al. Alcohol Clin Exp Res. 2007 May;31(5):829-36. Epub 2007 Mar 31

Hepatitis C virus infection among HIV-1 infected individuals from northern Mexico. Rivas-Estilla AM, et. al. Hepatol Res. 2007 May;37(5):311-6.

Association between hepatitis C virus coinfection and regional adipose tissue volume in HIV-infected men and women. Tien PC, et. al. J Acquir Immune Defic Syndr. 2007 May 1;45(1):60-5.

Health-related quality of life in HIV-1-infected patients on HAART: a five-years longitudinal analysis accounting for dropout in the APROCO-COPILOTE cohort (ANRS CO-8). Protopopescu C, et. al. Qual Life Res. 2007 May;16(4):577-91. Epub 2007 Feb 1

complementary and alternative therapies

Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized silymarin. Polyak SJ, et. al. Gastroenterology. 2007 May;132(5):1925-36. Epub 2007 Feb 21

Inhibition of HCV RNA-dependent RNA polymerase activity by aqueous extract from Fructus Ligustri Lucidi. Kong L, et al. Virus Res. 2007 May 23; [Epub ahead of print]

Oxidative-inflammatory damage in cirrhosis: Effect of vitamin E and a fermented papaya preparation. Marotta F, et al. J Gastroenterol Hepatol. 2007 May;22(5):697-703.

High-dose vitamins E and C supplementation prevents ribavirin-induced hemolytic anemia in patients with chronic hepatitis C. Kawaguchi Y, et al. Hepatol Res. 2007 May;37(5):317-24.

Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn.). Tamayo C, et. al. Integr Cancer Ther. 2007 Jun;6(2):146-57

miscellaneous works

Benefits and adverse effects of hepatitis C screening: early results of a screening program. Trepka MJ, et al. J Public Health Manag Pract. 2007 May-Jun;13(3):263-9.

Offers of hepatitis C care do not lead to treatment. Schackman BR, Teixeira PA, Beeder AB. J Urban Health. 2007 May;84(3):455-8.

Individual and Couple-Level Risk Factors for Hepatitis C Infection among Heterosexual Drug Users: A Multilevel Dyadic Analysis. McMahon JM, et. al. J Infect Dis. 2007 Jun 1;195(11):1572-81. Epub 2007 Apr 16

Overestimation and underestimation of hepatitis C virus RNA levels in a widely used real-time polymerase chain reaction-based method. Chevaliez S, et al. Hepatology. 2007 May 24; [Epub ahead of print]

Pretreatment preparation and management of interferon-based therapy for hepatitis C virus infection. Hopwood M, Treloar C. J Adv Nurs. 2007 May 25; [Epub ahead of print]

Cognitive reserve and neuropsychological functioning in patients infected with hepatitis C. Bieliauskas LA, et al. J Int Neuropsychol Soc. 2007 May 18;:1-6 [Epub ahead of print]

Assessing the Validity of Self-Reported Medication Adherence in Hepatitis C Treatment. Smith SR, et al. Ann Pharmacother. 2007 May 22; [Epub ahead of print]

Anger experiences among hepatitis C patients: relationship to depressive symptoms and health-related quality of life. Dan AA, et al. Psychosomatics. 2007 May-Jun;48(3):223-9.

Hazardous alcohol consumption and other barriers to antiviral treatment among hepatitis C positive people receiving opioid maintenance treatment. Watson B, et al. Drug Alcohol Rev. 2007 May;26(3):231-9.

Donate Now

Hepatitis C is the most common, chronic blood-borne
viral infection in the U.S.