Hepatitis C Legislation Reintroduced in Both Houses of Congress
C On The Rise In Washington
Cellular Protein Found That Interferes With Hepatitis C
A Cure For Hepatitis C Using Existing Treatments
"Health experts are warning of a "hidden health timebomb" that could explode in Calderdale. Nearly 1,000 people in the area are already infected by hepatitis C â€" and many more may be unaware they are carrying the disease. If untreated, its infection can lead to potentially fatal liver disease and liver cancer."
The Gay Hep C Subculture
After eliminating other causes for hep C transmission, researchers in three clinics in the United Kingdom found that unprotected group (rather than one-to-one) sex, unprotected anal sex and fisting were overwhelmingly more common in the men who caught hep C than a matched group of HIV-positive men who didn't. It also found that the vast majority of hepatitis C infections studied were linked with one of seven "clusters" of closely related hepatitis C viruses, the largest comprising nearly half of all those infected."
When HIV and Liver Disease Co-Exist
Hepatitis C and Its Long-Term Effects Are a Growing
"Five years ago, a woman named Sally in Seattle called me in Ohio to talk about her Hepatitis C. She was, as I recall, nearing 70 and a retired teacher. Her niece, an adult lawyer, had taken me to lunch to talk to me about her. She said Sally was the dearest sweetest woman; one whose husband was gone, had not had children, and was now alone. I was a columnist for the local newspaper and had been writing about my own Hepatitis C. For a year, I endured a clinical trial that was very much like chemotherapy. The niece told me Sally was afraid to have a liver biopsy, and wondered if I’d mind if her aunt called me."
Hepatitis C Drug Combo Shows Promise
European Union's CHMP Issues Positive Opinion on
PEGINTRON(Tm) and REBETOL(R) Combination Therapy for Hepatitis C in
Patients Coinfected with HIV
New Test Helps Identify Hepatitis C Patients at High Risk
of Developing Cirrhosis
Nurses Say Many May Have Hepatitis C And Not Know It
Alcohol and Hepatitis C Negatively Impact HIV
Nautilus OK'd to Test Hep C Drug
Hep C Infection May Increase Risk of Lymphoma: Virus can
hike chances of immune-system cancer by 30 percent, experts say
Researchers tracked 146,394 U.S. military veterans infected with the virus and 572,293 veterans who were not, and found that hepatitis C infection boosted the risk for non-Hodgkin’s lymphoma by 20 percent to 30 percent."
clinical trials, cohort studies, and pilot studies
Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Sarrazin C, et al. Gastroenterology. 2007 May;132(5):1767-77. Epub 2007 Feb 21.
A randomized trial of induction doses of interferon alone or in combination with ribavirin or ribavirin plus amantadine for treatment of nonresponder patients with chronic hepatitis C. Gramenzi A, et al. J Gastroenterol. 2007 May;42(5):362-7. Epub 2007 May 25.
Thyroid Cancer in HCV-Related Chronic Hepatitis Patients: A Case-Control Study. Antonelli A, et al. Thyroid. 2007 May;17(5):447-51.
Effects of dietary iron reduction versus phlebotomy in patients with chronic hepatitis C: results from a randomized, controlled trial on 40 Japanese patients. Sumida Y, et al. Intern Med. 2007;46(10):637-42. Epub 2007 May 24.
Paroxetine for prevention of depressive symptoms induced by interferon-alpha and ribavirin for hepatitis C. Raison CL, et. al. Aliment Pharmacol Ther. 2007 May 15;25(10):1163-74.
A randomized study on Peg-interferon alfa-2a with or without ribavirin in liver transplant recipients with recurrent hepatitis C. Angelico M, et. al. J Hepatol. 2007 Jun;46(6):1009-17. Epub 2007 Feb 5.
Risk of non-Hodgkin lymphoma and lymphoproliferative precursor diseases in US veterans with hepatitis C virus. Giordano TP, et.al. JAMA. 2007 May 9;297(18):2010-7
Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis. Pekow JR, et. al. Cancer. 2007 May 8;109(12):2490-2496 [Epub ahead of print]
High incidence of hepatitis C virus reinfection within a cohort of injecting drug users. Micallef JM, et. al. J Viral Hepat. 2007 Jun;14(6):413-8
Hepatitis C Virus Infection and the Development of Type 2 Diabetes in a Community-based Longitudinal Study. Wang CS, et. al. Am J Epidemiol. 2007 May 11; [Epub ahead of print]
Survival outcomes in liver transplantation for hepatocellular carcinoma, comparing impact of hepatitis C versus other etiology of cirrhosis. Bozorgzadeh A, et. al. Liver Transpl. 2007 May 30;13(6):807-813 [Epub ahead of print]
Mutation Rate of the Hepatitis C Virus NS5B in Patients Undergoing Treatment With Ribavirin Monotherapy. Lutchman G, et. al. Gastroenterology. 2007 May;132(5):1757-66. Epub 2007 Mar 24
Cognitive function does not worsen during pegylated interferon and ribavirin retreatment of chronic hepatitis C. Fontana RJ, et. al. Hepatology. 2007 May;45(5):1154-63
Liver fibrosis is associated with decreased peripheral platelet count in patients with chronic hepatitis B and C. Karasu Z, et. al. Dig Dis Sci. 2007 Jun;52(6):1535-9. Epub 2007 Apr 27
Antiviral response of HCV genotype 1 to consensus interferon and ribavirin versus pegylated interferon and ribavirin. Sjogren MH, et. al. Dig Dis Sci. 2007 Jun;52(6):1540-7. Epub 2007 Apr 4
Oral resiquimod in chronic HCV infection: Safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. Pockros PJ, et al. J Hepatol. 2007 May 4; [Epub ahead of print]
Baseline cholesterol is associated with the response to antiviral therapy in chronic hepatitis C. Economou M, et al. J Gastroenterol Hepatol. 2007 May 13; [Epub ahead of print]
Look-back study of Hepatitis C in teenagers after blood transfusions as neonates. Michal K, et al. Acta Paediatr. 2007 May 10; [Epub ahead of print]
Trends in post-liver transplant survival in patients with hepatitis C between 1991 and 2001 in the United States. Thuluvath PJ, et al. Liver Transpl. 2007 May;13(5):719-24.
The impact of insulin resistance, serum adipocytokines and visceral obesity on steatosis and fibrosis in patients with chronic hepatitis C. Lo Iacono O, et al. Aliment Pharmacol Ther. 2007 May 15;25(10):1181-91.
Diabetes mellitus reduces the therapeutic effectiveness of interferon-alpha2b plus ribavirin therapy in patients with chronic hepatitis C. Konishi I, et al. Hepatol Res. 2007 May;37(5):331-6.
A 5-year prospective study of the late resolution of chronic hepatitis C after antiviral therapy. Annicchiarico BE, et al. Aliment Pharmacol Ther. 2007 May 1;25(9):1039-46..
basic and applied science, pre-clinical studies
Factors Affecting Serum Concentrations of Hepatitis C Virus (HCV) RNA in HCV Genotype 1-Infected Patients with Chronic Hepatitis. Ticehurst JR, et al. J Clin Microbiol. 2007 May 30; [Epub ahead of print]
Cell surface expression of LDL-Receptor in chronic hepatitis C: correlation with viral load. Petit JM, et al. Am J Physiol Endocrinol Metab. 2007 May 1; [Epub ahead of print]
Monitoring the anti-viral effect of interferon-alpha on individual cells. Kim CS, et al. J Virol. 2007 May 30; [Epub ahead of print]
An infectious hepatitis C virus (HCV) cDNA clone (JFH1) was generated recently. However, quantitative analysis
Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus. Lavillette D, et al. J Virol. 2007 May 30; [Epub ahead of print]
Hepatitis C virus p7 and NS2 proteins are essential for infectious virus production. Jones CT, et al. J Virol. 2007 May 30; [Epub ahead of print]
Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02. Smyth CM, et.al. Eur J Gastroenterol Hepatol. 2007 Jun;19(6):493-498
An assessment of serum leptin levels in patients with chronic viral hepatitis: a prospective study. Manolakopoulos S, et. al. BMC Gastroenterol. 2007 May 31;7(1):17 [Epub ahead of print]
Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus. Yee LJ, et. al. Hepatology. 2007 May 24; [Epub ahead of print]
Monocyte-derived dendritic cell function in chronic hepatitis C is impaired at physiological numbers of dendritic cells. MacDonald AJ, et. al. Clin Exp Immunol. 2007 Jun;148(3):494-500. Epub 2007 Mar 15
Progression of Fibrosis during Chronic Hepatitis C Is Associated with Rapid Virus Evolution. Wang XH, et. al. J Virol. 2007 Jun;81(12):6513-22. Epub 2007 Feb 28
NS3 helicase and NS5B to 3' X regions are important for efficient JFH-1 replication in Huh7 cells. Murayama A, et. al. J Virol. 2007 May 23; [Epub ahead of print]
MRP2 haplotypes confer differential susceptibility to toxic liver injury. Choi JH, et. al. Pharmacogenet Genomics. 2007 Jun;17(6):403-415
Proangiogenic cytokines as hypoxia-dependent factors stimulating migration of human hepatic stellate cells. Novo E, et. al Am J Pathol. 2007 Jun;170(6):1942-53
Pretreatment sequence diversity differences in the full-length Hepatitis C Virus open reading frame correlate with early response to therapy. Donlin MJ, et al. J Virol. 2007 May 23; [Epub ahead of print]
Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection. Andréo U, et al. Cell Microbiol. 2007 May 21; [Epub ahead of print]
Hepatitis C virus induces the proteolytic cleavage of sterol regulatory element binding proteins (SREBPs) and stimulates the phosphorylation of SREBPs via oxidative stress. Waris G, et al. J Virol. 2007 May 16; [Epub ahead of print]
Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs. Chevalier C, et al. Mol Ther. 2007 May 15; [Epub ahead of print]
Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol. Pécheur EI, et al. Biochemistry. 2007 May 22;46(20):6050-9. Epub 2007 Apr 25.
Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. Danta M, et al. AIDS. 2007 May 11;21(8):983-991.
Awareness of hepatitis C diagnosis is associated with less alcohol use among persons co-infected with HIV. Tsui JI, et. al. J Gen Intern Med. 2007 Jun;22(6):822-5. Epub 2007 Feb 23
Hematologic toxicity associated with interferon-based hepatitis C therapy in HIV type 1-coinfected subjects. Behler CM, et. al. Clin Infect Dis. 2007 May 15;44(10):1375-83. Epub 2007 Apr 12.
Critical role of ribavirin for the achievement of early virological response to HCV therapy in HCV/HIV-coinfected patients. Ramos B, et. al. J Viral Hepat. 2007 Jun;14(6):387-91
Impact of hepatitis C on HIV progression in adults with alcohol problems. Cheng DM, et. al. Alcohol Clin Exp Res. 2007 May;31(5):829-36. Epub 2007 Mar 31
Hepatitis C virus infection among HIV-1 infected individuals from northern Mexico. Rivas-Estilla AM, et. al. Hepatol Res. 2007 May;37(5):311-6.
Association between hepatitis C virus coinfection and regional adipose tissue volume in HIV-infected men and women. Tien PC, et. al. J Acquir Immune Defic Syndr. 2007 May 1;45(1):60-5.
Health-related quality of life in HIV-1-infected patients on HAART: a five-years longitudinal analysis accounting for dropout in the APROCO-COPILOTE cohort (ANRS CO-8). Protopopescu C, et. al. Qual Life Res. 2007 May;16(4):577-91. Epub 2007 Feb 1
complementary and alternative therapies
Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized silymarin. Polyak SJ, et. al. Gastroenterology. 2007 May;132(5):1925-36. Epub 2007 Feb 21
Inhibition of HCV RNA-dependent RNA polymerase activity by aqueous extract from Fructus Ligustri Lucidi. Kong L, et al. Virus Res. 2007 May 23; [Epub ahead of print]
Oxidative-inflammatory damage in cirrhosis: Effect of vitamin E and a fermented papaya preparation. Marotta F, et al. J Gastroenterol Hepatol. 2007 May;22(5):697-703.
High-dose vitamins E and C supplementation prevents ribavirin-induced hemolytic anemia in patients with chronic hepatitis C. Kawaguchi Y, et al. Hepatol Res. 2007 May;37(5):317-24.
Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn.). Tamayo C, et. al. Integr Cancer Ther. 2007 Jun;6(2):146-57
Benefits and adverse effects of hepatitis C screening: early results of a screening program. Trepka MJ, et al. J Public Health Manag Pract. 2007 May-Jun;13(3):263-9.
Offers of hepatitis C care do not lead to treatment. Schackman BR, Teixeira PA, Beeder AB. J Urban Health. 2007 May;84(3):455-8.
Individual and Couple-Level Risk Factors for Hepatitis C Infection among Heterosexual Drug Users: A Multilevel Dyadic Analysis. McMahon JM, et. al. J Infect Dis. 2007 Jun 1;195(11):1572-81. Epub 2007 Apr 16
Overestimation and underestimation of hepatitis C virus RNA levels in a widely used real-time polymerase chain reaction-based method. Chevaliez S, et al. Hepatology. 2007 May 24; [Epub ahead of print]
Pretreatment preparation and management of interferon-based therapy for hepatitis C virus infection. Hopwood M, Treloar C. J Adv Nurs. 2007 May 25; [Epub ahead of print]
Cognitive reserve and neuropsychological functioning in patients infected with hepatitis C. Bieliauskas LA, et al. J Int Neuropsychol Soc. 2007 May 18;:1-6 [Epub ahead of print]
Assessing the Validity of Self-Reported Medication Adherence in Hepatitis C Treatment. Smith SR, et al. Ann Pharmacother. 2007 May 22; [Epub ahead of print]
Anger experiences among hepatitis C patients: relationship to depressive symptoms and health-related quality of life. Dan AA, et al. Psychosomatics. 2007 May-Jun;48(3):223-9.
Hazardous alcohol consumption and other barriers to antiviral treatment among hepatitis C positive people receiving opioid maintenance treatment. Watson B, et al. Drug Alcohol Rev. 2007 May;26(3):231-9.
C is the most common, chronic blood-borne