Caring Ambassadors Program

Hepatitis C Newsletter

www.HepCChallenge.org

August 2013

Clinical Trials, Cohort Studies, Pilot Studies

A pilot study of triple therapy with telaprevir, peginterferon and ribavirin for elderly patients with genotype 1 chronic hepatitis C. Hara T, Akuta N, Suzuki F, et al. J Med Virol. 2013 Jul 16. doi: 10.1002/jmv.23673. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23861088

Impaired mitochondrial β-oxidation in patients with chronic hepatitis C: relation with viral load and insulin resistance. Sato C, Saito T, Misawa K, et al. BMC Gastroenterol. 2013 Jul 10;13:112. doi: 10.1186/1471-230X-13-112.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711919/

Role of IL28B Gene Polymorphism and Cell-Mediated Immunity in Spontaneous Resolution of Acute Hepatitis C. Spada E, Amoroso P, Taliani G, et al. Clin Infect Dis. 2013 Jul 9. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23784926

A Diagnostic Score for the Prediction of Spontaneous Resolution of Acute Hepatitis C Virus Infection. Beinhardt S, Anna Payer B, Datz C, et al. J Hepatol. 2013 Jul 10. pii: S0168-8278(13)00446-7. doi: 10.1016/j.jhep.2013.06.028. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/23850880

Temperature Rise After Peginterferon Alfa-2a Injection in Patients with Chronic Hepatitis C is Associated with Virological Response and is Modulated by IL28B Genotype.

Han H, Noureddin M, Witthaus M, et al. J Hepatol. 2013 Jul 10. pii: S0168-8278(13)00451-0. doi: 10.1016/j.jhep.2013.07.004. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23850879

Effect of gender and ITPA polymorphisms on ribavirin-induced anemia in chronic hepatitis C patients. Scherzer TM, Stättermayer AF, Stauber R, et al. J Hepatol. 2013 Jul 10. pii: S0168-8278(13)00448-0. doi: 10.1016/j.jhep.2013.06.030. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23850877

Basic and Applied Science, Pre-Clinical Studies

Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8(+) T-Cell Exhaustion. Lee MS, Park CH, Jeong YH, Kim YJ, Ha SJ. PLoS Pathog. 2013 Jul;9(7):e1003478. doi: 10.1371/journal.ppat.1003478. Epub 2013 Jul 18.

http://www.ncbi.nlm.nih.gov/pubmed/23874199

Association Between Matrix Metalloproteinase (MMP)-2, MMP-9 and Total Antioxidant Status of Patients with Asymptomatic Hepatitis C Virus (HCV) Infection. Akca G, Tunçbilek S, Sepici-Dinçel A. Lett Appl Microbiol. 2013 Jul 11. doi: 10.1111/lam.12131. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23845113

Association of IL28B polymorphisms with virological response to peginterferon and ribavirin therapy in children and adolescents with chronic hepatitis C. Tajiri H, Tanaka Y, Takano T, et al. Hepatol Res. 2013 Jul 11. doi: 10.1111/hepr.12206. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23841718

Mannan binding lectin-associated serine protease 1 is induced by hepatitis C virus infection and activates human hepatic stellate cells. Saeed A, Baloch K, Brown RJ, et al. Clin Exp Immunol. 2013 Jul 11. doi: 10.1111/cei.12174. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23841802

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis. Amako Y, Igloi Z, Mankouri J, et al. J Biol Chem. 2013 Jul 15. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23857585

Evidence for two phylogenetic clusters within hepatitis C virus (HCV) genotype 2 inferred from analysis of complete coding sequences of 15 HCV strains. Jordier F, Deligny ML, Barré R, De Micco P, Cantaloube JF. J Med Virol. 2013 Jul 16. doi: 10.1002/jmv.23674. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23861126

HIV/HCV Coinfection

Combination Therapy With Telaprevir for Chronic Hepatitis C Virus Genotype 1 Infection in Patients With HIV: A Randomized Trial. Sulkowski MS, Sherman KE, Dieterich DT, et al. Ann Intern Med. 2013 Jul 16;159(2):86-96. doi: 10.7326/0003-4819-159-2-201307160-00654.

http://www.ncbi.nlm.nih.gov/pubmed/23685940

Chinese translation

Comparison of cognitive performance in HIV or HCV mono-infected and HIV-HCV co-infected patients. Ciccarelli N, Fabbiani M, Grima P, et al. Infection. 2013 Jul 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23839213

Expression of inhibitory markers is increased on effector memory T cells during hepatitis C virus/HIV coinfection as compared to hepatitis C virus or HIV monoinfection. Saha B, Choudhary MC, Sarin SK. AIDS. 2013 Jul 1. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23820090

Marijuana Smoking Does Not Accelerate Progression of Liver Disease in HIV-Hepatitis C Coinfection: A Longitudinal Cohort Analysis. Brunet L, Moodie EE, Rollet K, et al. Clin Infect Dis. 2013 Jul 4. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23811492

Epidemiology, Diagnostics, and Miscellaneous Works

Telaprevir: clinical pharmacokinetics, pharmacodynamics, and drug-drug interactions.

Kiang TK, Wilby KJ, Ensom MH. Clin Pharmacokinet. 2013 Jul;52(7):487-510. doi: 10.1007/s40262-013-0053-x.

http://www.ncbi.nlm.nih.gov/pubmed/23553423

Viral Hepatitis C Gets Personal - The Value of Human Genomics to Public Health. Zhang L, Gwinn M, Hu DJ. Public Health Genomics. 2013 Jul 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23859951

Hepatitis B or C viral infection and risk of pancreatic cancer: A meta-analysis of observational studies. Xu JH, Fu JJ, Wang XL, Zhu JY, Ye XH, Chen SD. World J Gastroenterol. 2013 Jul 14;19(26):4234-41. doi: 10.3748/wjg.v19.i26.4234.

http://www.ncbi.nlm.nih.gov/pubmed/23864789

The effect of hepatitis C treatment response on medical costs: a longitudinal analysis in an integrated care setting. Manos MM, Darbinian J, Rubin J, et al. J Manag Care Pharm. 2013 Jul-Aug;19(6):438-47.

http://www.ncbi.nlm.nih.gov/pubmed/23806057

Management of anemia induced by triple therapy in patients with chronic hepatitis C: challenges, opportunities and recommendations. Romero-Gómez M, Berenguer M, Molina E, Calleja JL. J Hepatol. 2013 Jul 15. pii: S0168-8278(13)00461-3. doi: 10.1016/j.jhep.2013.07.014. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23867320

Hepatitis C treatment in patients with kidney disease. Fabrizi F, Aghemo A, Messa P. Kidney Int. 2013 Jul 3. doi: 10.1038/ki.2013.264. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23823603

Women with chronic hepatitis C virus infection: recommendations for clinical practice.

Burton MJ, Brock JB, Geraci SA. South Med J. 2013 Jul;106(7):422-6. doi: 10.1097/ SMJ.0b013e31829b99f5.

http://www.ncbi.nlm.nih.gov/pubmed/23869458

Drug-drug interactions during antiviral therapy for chronic hepatitis C. Kiser JJ, Burton JR Jr, Everson GT. Nat Rev Gastroenterol Hepatol. 2013 Jul 2. doi: 10.1038/nrgastro.2013.106. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23817323

"It gives me a sense of belonging": Providing integrated health care and treatment to people with HCV engaged in a psycho-educational support group. Woolhouse S, Cooper E, Pickard A. Int J Drug Policy. 2013 Jul 13. pii: S0955-3959(13)00092-3. doi: 10.1016/j.drugpo.2013.05.018. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23860471

Frequent Emergency Department Visits are More Prevalent in Psychiatric, Alcohol Abuse, and Dual Diagnosis Conditions than in Chronic Viral Illnesses Such as Hepatitis and Human Immunodeficiency Virus. Minassian A, Vilke GM, Wilson MP. J Emerg Med. 2013 Jul 8. pii: S0736-4679(13)00467-8. doi: 10.1016/j.jemermed.2013.05.007. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23845528

Liver Cancer

Targeted Metabolic Profiling of Hepatocellular Carcinoma and Hepatitis C using LC-MS/MS. Baniasadi H, Nagana Gowda GA, et al. Electrophoresis. 2013 Jul 16. doi: 10.1002/elps.201300029. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23856972

Total serum glycan analysis is superior to Lectin-FLISA for the early detection of hepatocellular carcinoma. Comunale MA, Wang M, Anbarasan N, et al. Proteomics Clin Appl. 2013 Jul 16. doi: 10.1002/prca.201200125. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23857719

Incidence of hepatocellular carcinoma in patients with thalassemia who had hepatitis C.

Ansari S, Azarkivan A, Halagi F. Acta Med Iran. 2013 Jul 13;51(6):404-7.

http://www.ncbi.nlm.nih.gov/pubmed/23852846

Spontaneous clearance of serum hepatitis C virus RNA during the clinical course of hepatocellular carcinoma in patients with chronic hepatitis C.

Minami T, Tateishi R, Shiina S, et al. Hepatol Res. 2013 Jul 11. doi: 10.1111/hepr.12203. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23841664

Predictive factors of risk of hepatocellular carcinoma in chronic hepatitis C. Gavilán JC, Ojeda G, Arnedo R, Puerta S. Eur J Intern Med. 2013 Jul 9. pii: S0953-6205(13)00175-1. doi: 10.1016/j.ejim.2013.06.010. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23849588

Clinical features and outcome of cryptogenic hepatocellular carcinoma compared to those of viral and alcoholic hepatocellular carcinoma. Lee SS, Jeong SH, Byoun YS, et al. BMC Cancer. 2013 Jul 8;13:335. doi: 10.1186/1471-2407-13-335.

http://www.ncbi.nlm.nih.gov/pubmed/23829392

Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma. Cui J, Wang N, Zhao H, et al. Int J Cancer. 2013 Jul 3. doi: 10.1002/ijc.28372. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23825037

Role of Viral Genotypes and Hepatitis B Viral Mutants in the Risk of Hepatocellular Carcinoma Associated with Hepatitis B and C Dual Infection. Hung CH, Chen CH, Lee CM, et al. Intervirology. 2013 Jul 2. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/23838434

Protein Kinase R Modulates c-Fos and c-Jun Signaling to Promote Proliferation of Hepatocellular Carcinoma with Hepatitis C Virus Infection. Watanabe T, Hiasa Y, Tokumoto Y, et al. PLoS One. 2013 Jul 2;8(7):e67750. doi: 10.1371/journal.pone.0067750. Print 2013.

http://www.ncbi.nlm.nih.gov/pubmed/23844083